High dose rate brachytherapy optimization based on the generalized equivalent uniform dose

The result of cooperation between Pi Medical and University of Texas Health Science Center on biologically-based optimization, has been accepted for presentation as an oral communication in ESTRO 29, to be held in Barcelona, Spain from 12-16 September 2010.

Dose inhomogeneity is inherent in HDR brachytherapy treatment where high doses are delivered per fraction. Consequently, including biological parameters in the optimization procedure is highly important in order to more accurately correlate the clinical outcome with the treatment delivery plan. The use of the generalized equivalent uniform dose (gEUD) in the treatment plan optimization objective function is suggested by the current work as more effective in addressing inhomogeneity, compared to dose-based objectives.